Debasish Chattopadhyay's Structural Biology Laboratory is studying the DHFR and PTR enzymes of Trypanosoma cruzi for structure-based design of specific inhibitors of these enzymes. For this purpose, they have determined the crystal structure of substrate and inhibitor complexes of T. cruzi PTR at high resolution.
Full text article by Daniel E Lyman, Fernando A. Monteiro, Ananias A. Escalante, Celia Cordon-Rosales, Dawn M. Wesson, Jean-Pierre Dujardin, and Charles B. Beard.