Smith Lemli Opitz Syndrome Home>Conditions_and_Diseases>Genetic_Disorders>Smith Lemli Opitz Syndrome     Web Pages Smith Lemli Opitz Syndrome Advocacy and exchange. Includes a detailed description, diagnosis, the natural history, biochemistry, genetics, treatment and contact details. Emergency Medicine An extensive article about Smith-Lemli-Opitz syndrome, a multiple congenital anomalies/mental retardation syndrome caused by a defect in cholesterol synthesis. NORD: Smith Lemli Opitz Syndrome Offers a brief description, the synonyms and further resources.