Methotrexate Home>Pharmacy>Drugs_and_Medications>M>Methotrexate     Web Pages Methotrexate Used alone or in combination with chemotherapies, surgery or radiation for treatment of cancers, lymphomas, leukemias, rheumatoid arthritis, and severe psoriasis. (Amethopetrin, Folex, Folex PFS) Methotrexate - Familydoctor.org Information for patients in English and Spanish. Trexall and Methotrex Full prescribing information from RxList.